Objective:The aim of this study was to evaluate the effect of ibuprofen 800 mg on the pharmacokinetics of ibuprofen.
Methods:We conducted a single-center, randomized, double-blind, crossover study in healthy adults. Healthy adults were recruited and randomly assigned to receive 200 mg of ibuprofen. A total of 12 subjects were included in the study, and a total of 20 subjects were assigned to receive ibuprofen 400 mg/day. The primary endpoint was the area under the plasma concentration-time curve (AUC) for ibuprofen. The secondary endpoint was the area under the plasma concentration-time curve from 1 to 2 hours after treatment. The pharmacokinetics of ibuprofen were determined by the method of Köhler, Kollig and others, using liquid chromatography/tandem mass spectrometry. The mean area under the plasma concentration-time curve (AUC) of ibuprofen, ibuprofen 200 mg, ibuprofen 800 mg, ibuprofen 400 mg and ibuprofen 800 mg were compared with those of other NSAIDs.
Results:AUC of ibuprofen was reduced by 100% compared with other NSAIDs at the 10-hour (P < 0.05) and 200-mg doses, and by 88% compared with the lowest dose (P < 0.05) of ibuprofen. The mean AUC of ibuprofen was reduced by 66% compared with the lowest dose (P < 0.05) of ibuprofen. Ibuprofen had no effect on the pharmacokinetics of cyclooxygenase-2 (COX-2) inhibitors in healthy volunteers.
Conclusion:The present study demonstrated that ibuprofen was highly active at the 200-mg dose of ibuprofen, and at the 800-mg dose of ibuprofen. The ibuprofen-lower dose was well absorbed at the 400-mg dose, and at the 800-mg dose, the ibuprofen-lower dose was well absorbed at the 200-mg dose.
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Ibuprofen 800 mg Capsulelets are an extended-release (EAR) pain relief medication containing ibuprofen. Ibuprofen belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of prostaglandins, which are responsible for pain and inflammation. By reducing prostaglandins, ibuprofen helps to relieve pain and reduce fever.
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Get emergency medical help if you have a painful or prolonged period or have pain that is not controlled with ibuprofen or other pain relief medicationIbuprofen 800 mg Capsules are used to relieve mild to moderate pain and inflammation caused by:
Ibuprofen 800 mg Capsules may also be used for other purposes not listed on the product package.
Ibuprofen 800 mg Capsules may also be used for purposes other than those listed on the product package.
Take ibuprofen 800 mg Capsulelets by mouth with or without food, usually two to three times daily, for the shortest time needed. If pain is severe or persistent, the dose may need to be changed.
If you have missed a dose, take it as soon as possible and continue as you would normally. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
If you have missed a dose of ibuprofen 800 mg Capsulelets, you may skip the missed dose and continue with your regular dosing schedule.
The most common side effects of ibuprofen 800 mg Capsulelets are:
If you experience any severe or persistent side effects, such as allergic reactions, chest pain, shortness of breath, swelling, or difficulty breathing, seek medical attention immediately.
Do not take ibuprofen 800 mg Capsulelets if you are allergic to ibuprofen, aspirin, or any other painkillers. If you are taking aspirin or other painkillers that contain ibuprofen, inform your doctor before taking these medicines.
Medically reviewed by. Last updated on Oct 1, 2023.
Ibuprofen is used for treating pain and inflammation. It belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs).
Ibuprofen is available as a liquid suspension or chewable tablet.
Ibuprofen should be taken by mouth, usually once or twice daily. The dose is determined by the doctor. The maximum daily dose is 1000 mg. The maximum dose should not exceed 6,000 mg. If you take more than the recommended dose, it is advised to consult a doctor.
If you are using NSAIDs or have taken them before, your doctor will decide the dose.
Please note that Ibuprofen should not be used for children under 14 years of age unless other medicines are necessary. It is not known if it is safe or effective in children under 14 years of age.
Take ibuprofen exactly as your doctor tells you to take it. Ibuprofen is a liquid capsule.
You should drink a glass of water to help you get an adequate amount of liquid. If you have problems with your stomach, take ibuprofen with a glass of water.
If you are taking the liquid capsule form of ibuprofen, you should shake the bottle well before use.
You should wait at least 24 hours before taking ibuprofen to give the effect it has. If it is still not effective, you should try another form of ibuprofen.
Do not take ibuprofen if you are allergic to ibuprofen or any other NSAID ingredients (see "Other NSAIDs".
For further information, ask your doctor or pharmacist.
Keep ibuprofen in a cool, dry place, out of reach of children.
Ibuprofen is used to reduce the swelling and pain of conditions such as arthritis, backache and period pain. It is also used to reduce fever in conditions such as rheumatoid arthritis and ankylosing spondylitis.
In rare cases, ibuprofen can cause serious (rarely fatal) skin reactions in people with diabetes or kidney disease.
For immediate pain relief, the doctor will take a small amount of the liquid.
If you have a stomach ulcer, you may take ibuprofen with a meal.
It is not known whether ibuprofen is safe to have with people taking certain medications.
Do not take ibuprofen if you have been diagnosed with asthma or severe allergies.
Tell your doctor if you have taken an MAO inhibitor medicine, taken without telling your doctor.
Taking any other medicines can increase your risk of side effects.
If you have liver problems, talk to your doctor before taking any medicine.
Do not take Ibuprofen 800mg Tablets if you are allergic (hypersensitive) to ibuprofen or other related pain relievers. Avoid taking medicines containing ibuprofen if you are pregnant or breastfeeding. Inform your doctor about all other medicines you use, including over the counter medicines, vitamins and herbal supplements. Do not take Ibuprofen 800mg Tablets if you have liver or kidney problems. Inform your doctor if you have a history of stomach ulcers, asthma or hives.
This medicine is for adults and children over 12 years of age. Always read the label of the prescribed quantity before taking it.
If you forget to take this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at the same time.
Taking more than the recommended dose may increase the chance of side effects. It is advisable to consult your doctor or pharmacist if you have any questions about your medicine.
The most common side effects of this medicine include headache, indigestion, stomach pain, nausea and vomiting, diarrhea, rash or itching (especially in children, teenagers and young people), and stomach cramps, diarrhoea, constipation, flatulence, constipation with or without pain, dry mouth, headache, dizziness, or blurred vision. If you notice any other effects not listed above, contact your doctor or pharmacist.
If any other side effects persist or worsen, notify your doctor immediately.
Inform your doctor or pharmacist of any other medicines you are taking before starting this medicine.
Before taking Ibuprofen 800mg Tablets, tell your doctor or pharmacist if you are allergic to ibuprofen (such as acetaminophen or caffeine) or any other related pain relievers. Inform your doctor or pharmacist if you have any questions about your medicine.
If you are taking the medicine after the expiry date (EXP) printed on the pack, it is likely that the medicine has expired. Do not take the medicine after the expiry date.
Inform your pharmacist or doctor if you are using or have used the medicine in excess of the recommended dosage and for longer than recommended. Overuse of this medicine may lead to serious side effects.
Do not share this medicine with others even if they have the same symptoms as you. Excess of this medicine can cause serious side effects.
If you suspect an overdose of this medicine, be careful not to get rid of any symptoms immediately. Contact the doctor immediately if you experience any of the following symptoms: stomachache, feeling dizzy or tired, severe diarrhoea, constipation, flatulence, abdominal pain, or headache.
Immediately call your doctor for advice and seek emergency medical treatment if you notice any of the following symptoms: fever, chills, swollen joints, muscle pain, sore throat, muscle weakness or spasms, confusion, ringing in your ears, chest pain, or irregular heartbeat. Stop using this medicine immediately and contact the doctor for advice.
This medicine is used to treat pain and inflammation, and to treat fever and infections.This medicine is used to treat a painful and inflammatory condition. It may also be used to relieve pain and fever.Do not use Ibuprofen 800mg Tablets if:
If you have any questions, you can always contact a physician. The dosage for ibuprofen is based on the condition being treated. In the case of stomach or intestine, the dosage is 100mg every day. If your doctor has prescribed ibuprofen, he will give you a maximum of 400 mg. It is important to follow the instructions for the dosage. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, do not take a double dose. If your next dose is almost time for your next dose, skip the missed dose. Do not take two doses at once.
Do not take ibuprofen with food or milk if you have high blood sugar. If you have low blood sugar, it can cause serious problems. The dose will depend on the type of medicine. In the case of diabetes, you will need to take a higher dose than normal dose. If you have high blood sugar, your doctor will discuss with you with a doctor in case of high blood sugar. In the case of high blood sugar, you may be at risk of low blood sugar. The dosage will depend on the type of medicine. In the case of diabetes, you may be at risk of low blood sugar.
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